Light Replaces the Needle

Lighting Tech

 

Empa and the University Hospital Zurich have joined forces to develop a sensor that gauges blood sugar through skin contact. And best of all: No blood samples are necessary, not even to calibrate the sensor. “Glucolight” is initially to be used in premature babies to avoid hypoglycemia and subsequent brain damage.

One in 12 children are born prematurely in Switzerland. If hypoglycemia develops in these premature babies and persists for over an hour, it can affect brain development. In order to prevent this, the babies’ blood sugar levels need to be measured at regular intervals, which until now inevitably meant taking blood samples. Drawing blood regularly from the sensitive little ones for hours on end, however, is impossible as the blood loss and stress would be too great. In a project funded by the Swiss National Science Foundation (SNSF), Empa and the University Hospital Zurich thus teamed up to develop the sensor “Glucolight,” which gauges the blood sugar level through the skin without taking any blood. Although skin sensors already exist, they have to be calibrated before use, which means that the skin’s permeability value needs to be known. In order to establish this, the blood sugar value has to be determined via a blood sample and the glucose concentration on the skin measured. Based on these readings, the permeability can then be calculated and the sensor calibrated.  

Photo:  Credit: Empa 

A different method to previous sensors

Glucolight spares the premature babies blood samples and enables the blood sugar level to be monitored permanently thanks to the sensor’s novel measuring technology, which comprises several parts: 

• amicrodialysis measuring head, which was developed at the University Hospital Zurich, with a “smart” membrane developed at Empa

• light sources

• a pump

• a microfluidics chip with a fluorometer, also developed at the University Hospital Zurich

The smart Empa membrane contains special dye molecules, known as spiropyrans. If UV light is beamed onto these spiropyran molecules, they alter their chemical structure and become charged (polar). When irradiated with visible light, they revert to their original, neutral structure. As a result, the membrane “opens” if irradiated with UV light and glucose molecules diffuse relatively easily through the membrane from the skin. If irradiated with visible light, considerably fewer glucose molecules pass through the membrane.  

The measurement involves sticking the measuring head, which is around three centimeters in size, to the baby’s skin and irradiating it with visible light; some glucose molecules diffuse through the membrane from the skin. On the other side of the membrane, the glucose is mixed with a fluid and pumped through the microfluidics chip, while enzymes are added to trigger a reaction. During the reaction, a fluorescence appears, which the fluorometer measures, and the computer uses the reading to calculate the glucose concentration. The process is then repeated with UV light. The computer then uses these two different readings to calculate the premature baby’s blood sugar level.  

Research with and on Glucolight continues

The researchers filed a patent application for Glucolight in mid-2014 and the first clinical studies are scheduled at the University Hospital Zurich for 2015. However, it could be years before the use of Glucolight becomes standard. Empa and the University Hospital Zurich are currently in negotiations with partners for the industrial production of the sensor. For the future, the researchers also envisage the use of Glucolight in other fields, such as diabetes. 

 

Related Articles


Changing Scene

  • July 10, 2025 - Mac’s II Agencies Announce Addition to Project & Specification Sales Team

    Mac’s II Agencies Announces Addition to Project & Specification Sales Team

    Mac’s II Agencies is pleased to announce that Drazen Jerkovic will be joining their Project & Specification Sales team in the Lighting Division later this fall. With over 25 years of experience in the lighting and electrical industry, Drazen is a highly respected consultant known for his technical knowledge and deep understanding of project delivery. His recent role… Read More…

  • Noramco-Announces-Samantha-Boernsen-as-New-Regional-Sales-Manager-Winnipeg

    Noramco Announces Samantha Boernsen as New Regional Sales Manager, Winnipeg

    Please join Noramco in welcoming Samantha Boernsen as Regional Sales Manager, Winnipeg! Samantha brings a wealth of experience in the electrical industry, with a strong focus on lighting, marketing strategy, and customer engagement. She has built her career on connecting technical expertise with real-world application, making her a trusted partner to clients and colleagues alike.… Read More…


Design

  • Infrastructure Lighting Fixtures: Why Scale Matters

    Infrastructure Lighting Fixtures: Why Scale Matters

    In infrastructure projects, the size and scale of outdoor lighting fixtures are critical—not just for aesthetics, but for functionality, safety, and long-term performance. Whether lighting a streetscape, transit hub, or civic plaza, appropriately scaled fixtures help create environments that are both visually coherent and effectively illuminated. Public lighting plays a role in shaping how spaces… Read More…

  • What You Need to Consider When Choosing Data Center Lighting

    What You Need to Consider When Choosing Data Center Lighting

    When operating a data center, the lighting syst​em is often not the most concerned part. Actually, lighting system performance directly influences whole electricity consumption and operating costs, especially in a 24-hour non-stop data center. This article will delve into the key factors to be considered when choosing data center lighting. For enterprises that are planning to… Read More…


New Products

  • SATCO|NUVO: LED T12 Lamps

    SATCO|NUVO: LED T12 Lamps

    SATCO|NUVO’s LED T12 ballast compatible lamps are direct replacements for T12 linear fluorescent. Offered in a frosted white finish, these lamps are also PET coated and NSF rated. Conveniently sold in two-packs, these lamps make replacing traditional tubes an easy choice. Suggested applications include shop light fixtures, laundry room, utility closets, and garages. Read More…

  • BOLD: Prism Recessed Outdoor Fixture – RL-PRISM-60-BK

    BOLD: Prism Recessed Outdoor Fixture – RL-PRISM-60-BK

    The Prism is part of BOLD’s high-end, durable, and modern 60mm (2 3/8″) recessed fixtures. With its 93 CRI, hexagonal design, partially covered light source, and 360-degree warm glow, you can create unique ambient lighting effects and modern designs, minus the glare. You can safely walk or drive over these raised recessed lights: their low-profile… Read More…